US Navy Capt. Bill Urban said in a statement that the airstrike eliminated "an imminent ISIS-K threat” to the Hamid Karzai International Airport, referring to the Islamic State faction in Afghanistan.
Urban called the strike an act of “self-defense” and said military officials were still assessing the possibility of any civilian casualties.
“We are confident we successfully hit the target,” Urban said. “Significant secondary explosions from the vehicle indicated the presence of a substantial amount of explosive material.”
The Associated Press reported earlier Sunday that "multiple suicide bombers" had been targeted in a vehicle that was headed to the airport.
It was the second US military strike in Afghanistan since a suicide bomber killed 13 US service members and dozens of Afghans on Thursday at an airport gate, which officials blamed on ISIS-K.
On Saturday, officials said two ISIS-K members were killed in a US airstrike in the Nangarhar province.
A rocket attack that killed a child was also reported early Sunday in a neighborhood northwest of the airport, according to an Afghan police chief.